Environment and Climate Change Canada is a federal member agency and their representative chairs the Prairie Provinces Water Board. Environment and Climate Change Canada's mandate is to: preserve and enhance the quality of the natural environment, including water, air, soil, flora and fauna; conserve Canada's renewable resources. conserve and protect Canada's water resources; forecast weather and environmental change; enforce rules relating to boundary waters; and coordinate environmental policies and programs for the federal government.

The Agri-Environment Service Branch represents the federal Agriculture and Agri-Food Canada department on the Prairie Provinces Water Board. The branch was recently formed by merging the Prairie Farm Rehabilitation Administration, Agri-environmental Policy group, and the National Land and Water Information Service program. Agriculture and Agri-Food Canada provides information, research and technology, and policies and programs to achieve security of the food system, health of the environment and innovation for growth.

Alberta Environment and Parks is a member agency of the Prairie Provinces Water Board. Alberta Environment and Parks is a partner in protecting and enhancing Alberta's natural environment, to ensure the continued enjoyment of a clean and healthy environment by all. The department has staff in more than 120 communities throughout Alberta.

The Water Security Agency is the Saskatchewan member of the Prairie Provinces Water Board. The Water Security Agency leads management of the province's water resources to ensure safe drinking water sources and reliable water supplies for economic, environmental and social benefits for Saskatchewan people.

The Manitoba Minister and PPWB Board Member is from Manitoba Infrastructure. The Manitoba Infrastructure is responsible for the development of transportation policy and legislation, and for the management of the province’s vast infrastructure network. To meet these responsibilities, the department delivers a wide range of programs and services that play a critical role in sustaining the contributions of the transportation sector to Manitoba’s economic growth. As part of this mandate, the department manages the province's water infrastructure.

Manitoba Sustainable Development has the PPWB Board Alternate Member and many of the PPWB Committee Members for Manitoba. The department provides leadership in environmental stewardship for the benefit of current and future generations of Manitobans so the social, economic and inherent environmental value of water is protected and realized. Manitoba's water and fish resources are managed sustainably and people are safe from water hazards.